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<br />Animals that died showed hyperaemia and distension of abdomen and gut, whereas there were no gross lesions at necropsy in survivors Flickinger, In another examine with CFY rats. Most of the research are of adequate high quality and acceptable for risk characterization functions.<br /><br /><h2></h2><br />Although thyroid effects are a major finish-point in each human case-studies and animal studies, there is a lack of consistency in the results in the animal research. Resorcinol triggered no adverse effects in a number of reproduction and developmental toxicity studies in rats and rabbits. Resorcinol just isn't thought of to be genotoxic.<br /><br /><h3></h3><br />Especially in rats, lengthy-term perturbations of the pituitary—thyroid axis attributable to xenobiotics or physiological alterations e. For the thyroid, a non-statistically vital increase in TSH levels was reported for interim males, but not at scheduled necropsy. In high-dosed females, T three levels had been increased, while there was no impact on T 3 or T four ranges in males.<br /><br /><h1></h1><br /><br /><ul><br />  <br />  <br />  <br /> <li>Overall, the research are not adequate for a statistical extrapolation approach according to the EU Technical Guidance Document EC, a.</li><br />  <br />  <br />  <br /> <li>For the benthic and terrestrial compartments, the out there toxicity knowledge cannot be thought to be adequate for a quantitative risk characterization.</li><br />  <br />  <br />  <br /> <li>These figures agree nicely with the above exposure estimate based on the Yeung et al.</li><br />  <br />  <br />  <br /> <li>Assuming a physique weight of sixty four kg IPCS, provides an publicity estimate of zero.</li><br />  <br />  <br />  <br /> <li>However, owing to missing correlating histopathological changes within the three ranges of the mind examined and within the absence of a dose—response relationship, different indicators of developmental delay, or other changes in CNS function, these results weren't thought of as conclusive proof of a change in CNS perform.</li><br />  <br /> <br /> <br /></ul><br />A focus of 0. These substances had been found to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol in addition to 2- and 5-methylresorcinol had been reported to be At an iodide focus of zero.<br /><br />The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled pores and skin areas confirmed slight erythema and excessive dryness. Mean knowledge for 3 donors and sixteen replicates point out a plateau in receptor fluid focus between 24 and 48 h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats pressure not given;.<br />These figures agree well with the above exposure estimate based mostly on the Yeung et al.<br /><br /><h4></h4><br />In each species, there were no opposed effects on final imply body weights, haematology, or scientific chemistry parameters, and no chemical-associated gross or microscopic lesions were noticed. In one other research, rats had been exposed to zero or 0. No thyroid hormone measurements were carried out.
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